منابع مشابه
PPAR Medicines and Human Disease: The ABCs of It All
ATP-dependent binding cassette (ABC) transporters are a family of transmembrane proteins that pump a variety of hydrophobic compounds across cellular and subcellular barriers and are implicated in human diseases such as cancer and atherosclerosis. Inhibition of ABC transporter activity showed promise in early preclinical studies; however, the outcomes in clinical trials with these agents have n...
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Metabolic syndrome (MS), a condition characterized by multiple related clinical disorders including insulin resistance, central obesity, hyperlipidemia, hypertension, and heart disease, is an increasingly prevalent disease in industrialized societies. The intense research interest in the peroxisome proliferator-activated receptors (PPARs), by both the pharmaceutical industry and academia, stems...
متن کاملPPAR: A Pivotal Regulator in Metabolic Syndromes
Copyright: © 2012 Fei J. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Peroxisome Proliferator-Activated Receptor (PPAR) includes three isoforms: PPARα, PPARβ/δ and PPARγ. They are transcription factors acti...
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Peroxisome proliferator-activated receptor-γ (PPAR-γ) is a member of metabolic nuclear receptors called PPARs, which regulate all facets of the fatty acid metabolism including transport, synthesis, storage, mobilization, activation and oxidation of fatty acids. Hence, this receptor could be a drug target for metabolic syndrome-related noncommunicable diseases (NCD) like obesity, diabetes, cardi...
متن کاملIsoflavones and PPAR Signaling: A Critical Target in Cardiovascular, Metastatic, and Metabolic Disease
Isoflavone intake through foods and dietary supplements has both health advocates and critics. The latter come from a concern about the estrogenic effects of isoflavones in certain species. However, careful removal of isoflavones and other estrogens from the diet of rodents leads to the metabolic syndrome. These results suggest that isoflavones have other mechanisms of action, potentially those...
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ژورنال
عنوان ژورنال: Journal of Clinical Investigation
سال: 2006
ISSN: 0021-9738
DOI: 10.1172/jci28003